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"I'm very impressed. Previously we were using emitters from another manufacturer but after a trial of the Proxeon emitter I am now a committed user. The only problem for Proxeon is that they appear so robust I don't know when I will ever have to order another box!"
In nano electrospray MS, optimal performance generally requires flow rates from 10 nL/min to 500nL/min. The very narrow orifices of these emitters (1 - 30 µm) ensure that such low flow rates can be achieved.
Emitters together with the Thermo Scientific Nanospray Flex Ion Source enable use of the lowest possible flow rate, thereby conserving sample while still obtaining a strong signal. Their design takes advantage of the fact that the signal intensity observed in ES-MS is concentration dependent and not a function of total sample consumption.
For busy laboratories analyzing large numbers of samples, online nano electrospray analysis, using stainless steel emitters, is the first choice, facilitating automation and ensuring a higher throughput.
Offline analysis has several advantages when needing to extract the maximum information from very limited amounts of sample. Data can be averaged extensively to improve the S/N-ratio and conditions optimized for MS/MS experiments. Other technical advantages include: